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The Bacterial Amyloids Phenol Soluble Modulins from Catalyze Alpha-Synuclein Aggregation

Int J Mol Sci. 2021-10; 
Caroline Haikal, Lei Ortigosa-Pascual, Zahra Najarzadeh, Katja Bernfur, Alexander Svanbergsson, Daniel E Otzen, Sara Linse, Jia-Yi Li
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摘要

Aggregated α-synuclein (α-syn) is the main constituent of Lewy bodies, which are a pathological hallmark of Parkinson's disease (PD). Environmental factors are thought to be potential triggers capable of initiating the aggregation of the otherwise monomeric α-syn. Braak's seminal work redirected attention to the intestine and recent reports of dysbiosis have highlighted the potential causative role of the microbiome in the initiation of pathology of PD. is a bacterium carried by 30-70% of the general population. It has been shown to produce functional amyloids, called phenol soluble modulins (PSMαs). Here, we studied the kinetics of α-syn aggregation under quiescent conditions in the presence or absence o... More

关键词

Parkinson’s disease, aggregation, alpha-synuclein, bacterial amyloids, protein folding