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Modulation of the Conformational Space of SARS-CoV-2 RNA Quadruplex RG-1 by Cellular Components and the Amyloidogenic Peptides α-Synuclein and hIAPP

Chemistry. 2022-01; 
Sanjib K Mukherjee, Jim-Marcel Knop, Roland Winter
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Mammalian Expression … This method avoids ensemble averaging and enabled us to elucidate the structure and … Human IAPP (islet amyloid polypeptide or amylin) was purchased from GenScript (Leiden, … Get A Quote

摘要

Given the emergence of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), which particularly threatens older people with comorbidities such as diabetes mellitus and dementia, understanding the relationship between Covid-19 and other diseases is an important factor for treatment. Possible targets for medical intervention include G-quadruplexes (G4Qs) and their protein interaction partners. We investigated the stability and conformational space of the RG-1 RNA-G-quadruplex of the SARS-CoV-2 N-gene in the presence of salts, cosolutes, crowders and intrinsically disordered peptides, focusing on α-Synuclein and the human islet amyloid polypeptide, which are involved in Parkinson's disease (PD) and ty... More

关键词

RNA G-quadruplex, SARS-CoV-2, hIAPP, single-molecule FRET, α-synuclein