Products/Services Used | Details | Operation |
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Custom Vector Construction> | … of TRIM21 was injected over immobilized h9C12 … (GenScript Inc.), whereas vectors encoding h9C12 hinge swap and hinge-deleted variants were made by cDNA synthesis (GenScript … | Get A Quote |
Humans have four IgG antibody subclasses that selectively or differentially engage immune effector molecules to protect against infections. Although IgG1 has been studied in detail and is the subclass of most approved antibody therapeutics, increasing evidence indicates that IgG3 is associated with enhanced protection against pathogens. Here, we report that IgG3 has superior capacity to mediate intracellular antiviral immunity compared with the other subclasses due to its uniquely extended and flexible hinge region, which facilitates improved recruitment of the cytosolic Fc receptor TRIM21, independently of Fc binding affinity. TRIM21 may also synergize with complement C1/C4-mediated lysosomal degradation via c... More