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Cross-reactive immunogenicity of group A streptococcal vaccines designed using a recurrent neural network to identify conserved M protein linear epitopes

Vaccine. 2021-02; 
Jay A Spencer, Tom Penfound, Sanaz Salehi, Michelle P Aranha, Lauren E Wade, Rupesh Agarwal, Jeremy C Smith, James B Dale, Jerome Baudry
Products/Services Used Details Operation
GenParts™ DNA Fragments … Nucleotide pairs encoding the two vaccine proteins were synthesized (GenScript, Piscataway, NJ) to contain the 16 codon fragments in tandem. The … Get A Quote

摘要

The M protein of group A streptococci (Strep A) is a major virulence determinant and protective antigen. The N-terminal sequence of the protein defines the more than 200 M types of Strep A and also contains epitopes that elicit opsonic antibodies, some of which cross-react with heterologous M types. Current efforts to develop broadly protective M protein-based vaccines are directed at identifying potential cross-protective epitopes located in the N-terminal regions of cluster-related M proteins for use as vaccine antigens. In this study, we have used a comprehensive approach using the recurrent neural network ABCpred and IEDB epitope conservancy analysis tools to predict 16 residue linear B-cell epitopes from ... More

关键词

Bioinformatics, Linear epitopes, M protein, Neural networks, Streptococcus pyogenes (S. pyogenes), Vaccine development