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Protective effects of guarana () against methotrexate-induced intestinal damage in mice

Food Sci Nutr. 2021-05; 
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摘要

This study aimed to examine the effects of guarana () on intestinal damage induced by MTX in mice. Mice were classified into four groups: control, MTX, guarana (), and guarana () together with MTX. Total antioxidant capacity together with glutathione, superoxide dismutase, MDA, ALT, AST, myeloperoxidase, total protein and IL-1β were detected in the serum. Bax and Bcl2 expressions were detected in intestine together with histopathological examination and immunohistochemical examination of caspase-9. Intoxication with MTX inhibited antioxidant and promoted myeloperoxidase activity in experimental mouse models but pre-administration of guarana ameliorated this effect by inhibiting IL-1β. Real-time quantitative P... More

关键词

Bcl2, IL‐1β, Paullinia cupana, caspase 9, enteritis, methotrexate