至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Grass Carp () NIMA-Related Kinase 6 Blocks dsRNA-Induced IFN I Response by Targeting IRF3

Front Immunol. 2021-01; 
Xiaowen Xu, Meifeng Li, Zeyuan Deng, Jihuan Hu, Zeyin Jiang, Yapeng Liu, Kaile Chang, Chengyu Hu
Products/Services Used Details Operation
ORF cDNA Clones/MolecularCloud … sequence of CiNEK6. The largest ORF frame of CiNEK6 was found by ORF Finder server (https://www.genscript.com/sms2/orf_find.html). Multiple amino … Get A Quote

摘要

Accumulating evidence indicates that mammalian NIMA (never in mitosis, gene A)-related kinase 6 (NEK6) plays potential roles during the course of tumorigenesis, but little is known about NEK6 in lower vertebrates. Herein, we reported a mammalian ortholog of NEK6 in grass carp () (CiNEK6). Multiple alignment of amino acid sequences and phylogenetic analysis showed that CiNEK6 shares a high level of sequence similarity with its counterparts in birds. CiNEK6 was ubiquitously expressed in all tested tissues, and its expression level was increased under treatment with GCRV (dsRNA virus) or poly I:C (dsRNA analog). Q-PCR and dual-luciferase assays suggested that CiNEK6 overexpression suppressed IFN I activity in CIK ... More

关键词

IFN I, IRF3-mediated antiviral responses, NEK6, fish, inhibitor