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Septin 4 activates PPARγ/LXRα signaling by upregulating ABCA1 and ABCG1 expression to inhibit the formation of THP-1 macrophage-derived foam cells

Exp Ther Med. 2021-05; 
Xiaoying Song, Guoliang Yan, Haihui Wang, Danfei Lou
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Custom DNA/RNA Oligos … system; Thermo Fisher Scientific, Inc.). The primers were synthesized by Nanjing Genscript Biotechnology Co., Ltd. The thermocycling conditions were as … Get A Quote

摘要

Septin 4 is a member of a family of GTP-binding proteins that has been previously reported regulate cytoskeletal organization. In addition, it has been suggested to serve a role in atherosclerosis. Therefore, the present study aimed to investigate the effects of Septin 4 on foam cell formation. THP-1 cells were first exposed to phorbol-12-myristate-13-acetate for differentiation into macrophages before being transformed into foam cells by treatment with oxidized low-density lipoprotein (ox-LDL). Septin 4 expression was then knocked down or overexpressed in THP-1 cells using transfection, whilst peroxisome proliferator activated receptor γ (PPARγ) was also inhibited using its selective antagonist (T0070907) in... More

关键词

atherosclerosis, foam cell, macrophage, peroxisome proliferator activated γ, septin 4