Products/Services Used | Details | Operation |
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Catalog Peptides> | … used to stimulate T cells were provided by GenScript … microglobulin and 5 mg of peptide (Genscript) into a buffer of 3M Urea, 0.5 M L-Arginine, 0.1 M Tris-HCl … | Get A Quote |
The emergence of the SARS-CoV-2 Omicron variant has raised concerns of escape from vaccine-induced immunity. A number of studies have demonstrated a reduction in antibody-mediated neutralization of the Omicron variant in vaccinated individuals. Preliminary observations have suggested that T cells are less likely to be affected by changes in Omicron. However, the complexity of human leukocyte antigen genetics and its impact upon immunodominant T cell epitope selection suggests that the maintenance of T cell immunity may not be universal. In this study, we describe the impact that changes in Omicron BA.1, BA.2 and BA.3 have on recognition by spike-specific T cells. These T cells constitute the immunodominant CD8 ... More