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P2X7R in Mast Cells is a Potential Target for Salicylic Acid and Aspirin in Treatment of Inflammatory Pain

J Inflamm Res. 2021-07; 
Yucui Jiang, Fan Ye, Ying Du, Yingxin Zong, Zongxiang Tang
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Custom DNA/RNA Oligos … C for 5 min, 40 cycles of 15 s at 95 °C, 30 s at 60°C (56 °C for P2X4R), 1 min at 72 °C, and 10 min at 72 °C. The PCR primers were synthesized by GenScript Biotech (Nanjing, China) … Get A Quote

摘要

background: Mast cells are well known for their role in inflammatory pain. P2X7 receptor (P2X7R) has attracted much attention due to its prominent role in inflammatory diseases. Salicylates are commonly used anti-inflammatory and analgesic drugs. Until now, little has been known about whether P2X7R in mast cells is involved in inflammatory pain and whether it is a potential target for salicylates. methods: First, the expression of P2X receptors in mouse peritoneal mast cells was detected by using RT-PCR, immunofluorescence, calcium imaging and electrophysiological technique. In addition, the functions of P2X receptors, especially P2X7R, in mast cells were studied by using QPCR, ELISA and behavioral tests. Furth... More

关键词

P2X7R, analgesia, inflammatory pain, mast cells, salicylates