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FOXA1 is a determinant of drug resistance in breast cancer cells

Breast Cancer Res Treat. 2021-01; 
Uttom Kumar, Anastasia Ardasheva, Zimam Mahmud, R Charles Coombes, Ernesto Yagüe
Products/Services Used Details Operation
PCR Cloning and Subcloning … FOXA1 cDNA was synthesized by GenScript Biotech and cloned into the XhoI and EcoRI … 24E10 for E-cadherin (Cell Signaling Technology), Q6 (Santa Cruz Biotechnology) for FOXA1 … Get A Quote

摘要

objective: Breast cancer is one of the most commonly diagnosed cancers in women. Five subtypes of breast cancer differ in their genetic expression profiles and carry different prognostic values, with no treatments available for some types, such as triple-negative, due to the absence of genetic signatures that could otherwise be targeted by molecular therapies. Although endocrine treatments are largely successful for estrogen receptor (ER)-positive cancers, a significant proportion of patients with metastatic tumors fail to respond and acquire resistance to therapy. FOXA1 overexpression mediates endocrine therapy resistance in ER-positive breast cancer, although the regulation of chemotherapy response by FOXA1 h... More

关键词

Anchorage independence, Breast cancer, E-cadherin, FOXA1, Multidrug resistance