至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

PEAK1 promotes invasion and metastasis and confers drug resistance in breast cancer

Clin Exp Med. 2021-09; 
Xingang Wang, Yan Zheng, Yu Wang
Products/Services Used Details Operation
Custom Vector Construction … Viral particles were produced by GenScript Biotechnology, China. Viral particles containing PEAK1 overexpressing vectors or control vectors were used to infect MCF-7 cells … Get A Quote

摘要

Pseudopodium-enriched atypical kinase 1 (PEAK1) has been reported to be upregulated in human malignancies and is correlated with a poor prognosis. Enhanced PEAK1 expression facilitates tumor cell survival, invasion, metastasis and chemoresistance. However, the role of PEAK1 in breast cancer is unclear. We investigated PEAK1 expression in breast cancer and analyzed the relationship with clinicopathological status and chemotherapy resistance. We also investigated the role of PEAK1 in breast cancer cells in vitro and in vivo. Immunohistochemistry for PEAK1 was performed in 112 surgically resected breast cancer tissues. The association between clinicopathological status, chemotherapy resistance and PEAK1 expression... More

关键词

Breast cancer, Chemotherapy resistance, Metastasis, Pseudopodium-enriched atypical kinase 1