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The Anti-apoptotic Role of 3'-Untranslational Region in Response to Angiotensin II via Mcl1 Expression

Front Cell Dev Biol. 2021-01; 
Dayin Lyu, Hong Yan, Liyang Chen, Lingmin Zhang, Yanfeng Du, Lexi Ding, Qiulun Lu
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Custom DNA/RNA Oligos … DNA sequence of 3′-UTR of mouse Mcl1 was synthesized from GenScript Corp. Subsequently, the sequence was amplified by PCR. The primers were as follows: Mcl1-UTR, forward 5… Get A Quote

摘要

Myeloid cell leukemia 1 (Mcl1), an abundant protein in the myocardium, plays an essential role in fibrosis and anti-inflammation in cardiomyocytes to prevent heart failure. However, whether 3'-untranslated regions (3'-UTR) has the cardio-protecting function remains unclear. Down-regulation of Mcl1 was observed in adult mice heart tissues after Angiotensin II (Ang II) treatment. Consistent with results, the reduction of Mcl1 expression was identified in Ang II-treated neonatal cardiomyocytes. Mechanistically, 3'-UTR prevented Ang II-induced cardiac apoptosis via up-regulation of Mcl1 and an angiogenic factor with a G-patch domain and a forkhead-associated domain 1 (Aggf1), which plays cardiac-protective role.... More

关键词

3′-UTR, Ang II, Mcl1, anti-apoptosis, heart failure