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Specificity and Reactivity of Serine/Threonine Kinases PknG and PknB

J Chem Inf Model. 2022-03; 
Osvaldo Burastero, Marisol Cabrera, Elias D Lopez, Lucas A Defelipe, Juan Pablo Arcon, Rosario Durán, Marcelo A Marti, Adrian G Turjanski
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Catalog Peptides … The wild-type (WT) and doubly mutated 17-mer peptides were purchased from GenScript, NJ. The WT sequence concerned the residues 14–30 of GarA (SDEVTVE T21TSVFRADFL). … Get A Quote

摘要

(Mtb), the causative agent of Tuberculosis, has 11 eukaryotic-like serine/threonine protein kinases, which play essential roles in cell growth, signal transduction, and pathogenesis. Protein kinase G (PknG) regulates the carbon and nitrogen metabolism by phosphorylation of the glycogen accumulation regulator (GarA) protein at Thr21. Protein kinase B (PknB) is involved in cell wall synthesis and cell shape, as well as phosphorylates GarA but at Thr22. While PknG seems to be constitutively activated and recognition of GarA requires phosphorylation in its unstructured tail, PknB activation is triggered by phosphorylation of its activation loop, which allows binding of the forkhead-associated domain of GarA. In the... More

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