Products/Services Used | Details | Operation |
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Catalog Peptides> | Mice were treated intranasally with 10 μg papain (Worthington) and 50 μg 2W1S peptide (peptide sequence: EAWGALANWAVDSA, GenScript) diluted in sterile PBS on Day 0, Day 1 and Day 15, the mice were then euthanized on Day 20 for analysis | Get A Quote |
Group 3 innate lymphoid cells (ILC3s) critically regulate host-microbe interactions in the gastrointestinal tract, but their role in the airway remains poorly understood. Here, we demonstrate that lymphoid-tissue-inducer (LTi)-like ILC3s are enriched in the lung-draining lymph nodes of healthy mice and humans. These ILC3s abundantly express major histocompatibility complex class II (MHC class II) and functionally restrict the expansion of allergen-specific CD4 T cells upon experimental airway challenge. In a mouse model of house-dust-mite-induced allergic airway inflammation, MHC class II ILC3s limit T helper type 2 (Th2) cell responses, eosinophilia, and airway hyperresponsiveness. Furthermore, MHC class II I... More