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miR-24 controls the regenerative competence of hair follicle progenitors by targeting Plk3

Cell Rep. 2021-06; 
Fengzhen Liu, Xia Zhang, You Peng, Liping Zhang, Yao Yu, Peng Hua, Peiying Zhu, Xinyu Yan, Yin Li, Liang Zhang
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摘要

Maintaining a suitable level of sensitivity to environmental cues is crucial for proper function of adult stem cells. Here, we explore how the intrinsic sensitivity of skin hair follicle (HF) progenitors to growth stimuli is dynamically regulated. We discover miR-24 is an miRNA whose expression in HF progenitors inversely correlates with their growth potency in vivo. We show that its upregulation in adult skin epithelium leads to blunted responses of HF progenitors to growth cues and retards hair regeneration, while its conditional ablation leads to hyper-sensitized growth responsiveness of HF progenitors and precocious hair regeneration. Mechanistically, we find that miR-24 limits the intrinsic growth compe... More

关键词

hair follicle, microRNA, polo-like kinase, stem cell, tissue regeneration