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Brain adiponectin signaling controls peripheral insulin response in Drosophila

Nat Commun. 2021-09; 
Nathalie Arquier, Marianne Bjordal, Philippe Hammann, Lauriane Kuhn, Pierre Léopold
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Custom Vector Construction UAS-AdipoR-Myc was obtained from cloning a synthetic AdipoR cDNA (GeneSynthesis; GenScript) into a Myc-tagged-UAS as destination vector (Carnegie Institution of Washington Vector collection Get A Quote

摘要

The brain plays a key role in energy homeostasis, detecting nutrients, metabolites and circulating hormones from peripheral organs and integrating this information to control food intake and energy expenditure. Here, we show that a group of neurons in the Drosophila larval brain expresses the adiponectin receptor (AdipoR) and controls systemic growth and metabolism through insulin signaling. We identify glucose-regulated protein 78 (Grp78) as a circulating antagonist of AdipoR function produced by fat cells in response to dietary sugar. We further show that central AdipoR signaling inhibits peripheral Juvenile Hormone (JH) response, promoting insulin signaling. In conclusion, we identify a neuroendocrine axis w... More

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