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The extracellular innate-immune effector HMGB1 limits pathogenic bacterial biofilm proliferation

J Clin Invest. 2021-08; 
Aishwarya Devaraj, Laura A Novotny, Frank H Robledo-Avila, John R Buzzo, Lauren Mashburn-Warren, Joseph A Jurcisek, Natalia O Tjokro, Santiago Partida-Sanchez, Lauren O Bakaletz, Steven D Goodman
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Bacterial Expression Bacterial endotoxin test via ToxinSensor Chromogenic LAL endotoxin kit (Genscript) was performed prior to use. Get A Quote

摘要

Herein, we describe an extracellular function of the vertebrate high-mobility group box 1 protein (HMGB1) in the proliferation of bacterial biofilms. Within host cells, HMGB1 functions as a DNA architectural protein, similar to the ubiquitous DNABII family of bacterial proteins; despite that, these proteins share no amino acid sequence identity. Extracellularly, HMGB1 induces a proinflammatory immune response, whereas the DNABII proteins stabilize the extracellular DNA-dependent matrix that maintains bacterial biofilms. We showed that when both proteins converged on extracellular DNA within bacterial biofilms, HMGB1, unlike the DNABII proteins, disrupted biofilms both in vitro (including the high-priority ESKAP... More

关键词

Bacterial infections, Drug therapy, Immunology, Immunotherapy, Infectious disease