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An AAV-based, room-temperature-stable, single-dose COVID-19 vaccine provides durable immunogenicity and protection in non-human primates

Cell Host Microbe. 2021-08; 
Nerea Zabaleta, Wenlong Dai, Urja Bhatt, Cécile Hérate, Pauline Maisonnasse, Jessica A Chichester, Julio Sanmiguel, Reynette Estelien, Kristofer T Michalson, Cheikh Diop, Dawid Maciorowski, Nathalie Dereuddre-Bosquet, Mariangela Cavarelli, Anne-Sophie Gallouët, Thibaut Naninck, Nidhal Kahlaoui, Julien Lemaitre, Wenbin Qi, Elissa Hudspeth, Allison Cucalon, Cecilia D Dyer, M Betina Pampena, James J Knox, Regina C LaRocque, Richelle C Charles, Dan Li, Maya Kim, Abigail Sheridan, Nadia Storm, Rebecca I Johnson, Jared Feldman, Blake M Hauser, Vanessa Contreras, Romain Marlin, Raphaël Ho Tsong Fang, Catherine Chapon, Sylvie van der Werf, Eric Zinn, Aisling Ryan, Dione T Kobayashi, Ruchi Chauhan, Marion McGlynn, Edward T Ryan, Aaron G Schmidt, Brian Price, Anna Honko, Anthony Griffiths, Sam Yaghmour, Robert Hodge, Michael R Betts, Mason W Freeman, James M Wilson, Roger Le Grand, Luk H Vandenberghe
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Monoclonal Antibody Services anti-SARS-CoV-2 Spike monoclonal neutralizing(GenScript Get A Quote

摘要

The SARS-CoV-2 pandemic has affected more than 185 million people worldwide resulting in over 4 million deaths. To contain the pandemic, there is a continued need for safe vaccines that provide durable protection at low and scalable doses and can be deployed easily. Here, AAVCOVID-1, an adeno-associated viral (AAV), spike-gene-based vaccine candidate demonstrates potent immunogenicity in mouse and non-human primates following a single injection and confers complete protection from SARS-CoV-2 challenge in macaques. Peak neutralizing antibody titers are sustained at 1 year and complemented by functional memory T cell responses. The AAVCOVID vector has no relevant pre-existing immunity in humans and does not elic... More

关键词

AAV, COVID-19, SARS-CoV-2, adeno-associated virus, durability, immunization, room-temperature stable, single dose, vaccine, viral challenge