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Influence of Fc modifications and IgG subclass on biodistribution of humanized antibodies targeting L1CAM

J Nucl Med. 2021-08; 
Sai Kiran Sharma, Maya Suzuki, Hong Xu, Joshua A Korsen, Zachary Samuels, Hongfen Guo, Brandon Nemieboka, Alessandra Piersigilli, Kimberly J Edwards, Nai-Kong Cheung, Jason S Lewis
Products/Services Used Details Operation
Gene Synthesis The huE71 genes (either wildtype or Fcmodified) were synthesized (Genscript, Piscataway, NY) Get A Quote

摘要

关键词

Afucosylated antibody, Aglycosylated antibody, Fab Arm Exchange, Fc receptor, Immuno-PET, Molecular Imaging, Monoclonal Antibodies, PET