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PGLYRP2 as a novel biomarker for the activity and lipid metabolism of systemic lupus erythematosus

Lipids Health Dis. 2021-08; 
Hui Li, Defang Meng, Jieting Jia, Hua Wei
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Custom DNA/RNA Oligos Relative level was calculated by the 2–ΔΔCt method, with GAPDH as the internal reference. Gene-specific primers (Genscript Biotech, Nanjing, China) Get A Quote

摘要

background: To assess the value of peptidoglycan recognition protein 2 (PGLYRP2) in assessing the disease activity and lipid metabolism in patients with systemic lupus erythematosus (SLE). methods: SLE patients with stable disease (n = 15), active lupus nephritis (LN) (n = 15) and neuropsychiatric systemic lupus erythematosus (NP-SLE) (n = 15) admitted to Northern Jiangsu People's Hospital (Jiangsu, China) in 2019-2020 were recruited. In addition, volunteers with matched age and sex (n = 15) were enrolled as controls. The level of PGLYRP2 in the serum and its expression in peripheral blood mononuclear cells (PBMCs) were measured. The link between PGLYRP2 level and clinical parameters (including ... More

关键词

Lipid profile, PGLYRP2, SLE disease activity index, Systemic lupus erythematosus