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Candida albicans and Candida glabrata triosephosphate isomerase - a moonlighting protein that can be exposed on the candidal cell surface and bind to human extracellular matrix proteins

BMC Microbiol. 2021-07; 
Dorota Satala, Grzegorz Satala, Marcin Zawrotniak, Andrzej Kozik
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摘要

background: Triosephosphate isomerase (Tpi1) is a glycolytic enzyme that has recently been reported also to be an atypical proteinaceous component of the Candida yeast cell wall. Similar to other known candidal "moonlighting proteins", surface-exposed Tpi1 is likely to contribute to fungal adhesion during the colonization and infection of a human host. The aim of our present study was to directly prove the presence of Tpi1 on C. albicans and C. glabrata cells under various growth conditions and characterize the interactions of native Tpi1, isolated and purified from the candidal cell wall, with human extracellular matrix proteins. results: Surface plasmon resonance measurements were used to determine the dissoc... More

关键词

collagen, elastin, extracellular matrix, fibronectin, laminin, moonlighting proteins, non-albicans Candida species, triosephosphate isomerase, vitronectin