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Human low-density lipoprotein receptor plays an important role in hepatitis B virus infection

PLoS Pathog. 2021-07; 
Yingying Li, Guangxiang Luo
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Monoclonal Antibody Services The LDLR-blocking monoclonal antibody C7, which was described previously [41], was produced from a hybridoma obtained from ATCC (CRL-1691) and were purified through affinity chromatography by GenScript (Piscataway, NJ) Get A Quote

摘要

Hepatitis B virus (HBV) chronically infects more than 240 million people worldwide, resulting in chronic hepatitis, cirrhosis, and hepatocellular carcinoma. HBV vaccine is effective to prevent new HBV infection but does not offer therapeutic benefit to hepatitis B patients. Neither are current antiviral drugs curative of chronic hepatitis B. A more thorough understanding of HBV infection and replication holds a great promise for identification of novel antiviral drugs and design of optimal strategies towards the ultimate elimination of chronic hepatitis B. Recently, we have developed a robust HBV cell culture system and discovered that human apolipoprotein E (apoE) is enriched on the HBV envelope and promotes H... More

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