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Omega-Class Glutathione Transferases of Carcinogenic Liver Fluke, C, Modulate Apoptosis and Differentiation of Host Cholangiocyteslo n o r c h i s s i n e n s i s

Antioxidants (Basel). 2021-06; 
Chun-Seob Ahn, Jeong-Geun Kim, Insug Kang, Yoon Kong
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摘要

The small liver fluke causes hepatobiliary ductal infections in humans. Clonorchiasis is characterized histopathologically by ductal dysplasia, hyperplasia and metaplasia, which closely resembles cholangiocarcinoma (CCA). The disruption of programmed cell death is critical for malignant transformation, while molecular events underlying these phenomena have poorly been understood in clonorchiasis-related CCA tumorigenesis. We incorporated recombinant omega-class glutathione transferase (rCsGSTo) 1 or 2 into human intrahepatic biliary epithelial cells (HIBECs) and analyzed pathophysiological alterations of HIBECs upon the application of oxidative stress. rCsGSTos partially but significantly rescued HIBECs from ... More

关键词

Clonorchis sinensis, cell differentiation, cholangiocyte, gene regulation, omega-class glutathione transferase, oxidative stress, programmed cell death, protein kinase