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Cell surface GRP78 and Dermcidin cooperate to regulate breast cancer cell migration through Wnt signaling

Oncogene. 2021-05; 
Tyson W Lager, Clay Conner, Claudia R Keating, Jane N Warshaw, Athanasia D Panopoulos
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ORF cDNA Clones/MolecularCloud DCD-FLAG construct (ORF clone OHu30172) was purchased from Genscript. Get A Quote

摘要

The heat shock protein GRP78 typically resides in the endoplasmic reticulum in normal tissues, but it has been shown to be expressed on the cell surface of several cancer cells, and some stem cells, where it can act as a signaling molecule by not-yet-fully defined mechanisms. Although cell surface GRP78 (sGRP78) has emerged as an attractive chemotherapeutic target, understanding how sGRP78 is functioning in cancer has been complicated by the fact that sGRP78 can function in a cell-context dependent manner, with a diverse array of reported binding partners, to regulate a variety of cellular responses. We had previously shown that sGRP78 was important in regulating pluripotent stem cell (PSC) functions, and hypot... More

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