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Tick Importin-α Is Implicated in the Interactome and Regulome of the Cofactor Subolesin

Pathogens. 2021-04; 
Sara Artigas-Jerónimo, Margarita Villar, Alejandro Cabezas-Cruz, Grégory Caignard, Damien Vitour, Jennifer Richardson, Sandrine Lacour, Houssam Attoui, Lesley Bell-Sakyi, Eleonore Allain, Ard M Nijhof, Nina Militzer, Sophia Pinecki Socias, José de la Fuente
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Bacterial Expression Recombinant SUB and I. scapularis recombinant Importin-α fused to glutathione-S-transferase (GST), also produced in E. coli (commercially synthesized by GenScript, Piscataway, NJ, USA) Get A Quote

摘要

Ticks and tick-borne diseases (TBDs) represent a burden for human and animal health worldwide. Currently, vaccines constitute the safest and most effective approach to control ticks and TBDs. Subolesin (SUB) has been identified as a vaccine antigen for the control of tick infestations and pathogen infection and transmission. The characterization of the molecular function of SUB and the identification of tick proteins interacting with SUB may provide the basis for the discovery of novel antigens and for the rational design of novel anti-tick vaccines. In the present study, we used the yeast two-hybrid system (Y2H) as an unbiased approach to identify tick SUB-interacting proteins in an cDNA library, and studied ... More

关键词

akirin, epigenetic, histone, importin, interactome, regulome, subolesin, tick