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CD27CD38 plasmablasts are activated B cells of mixed origin with distinct function

iScience. 2021-04; 
Angeline Rouers, Ramapraba Appanna, Marion Chevrier, Josephine Lum, Mai Chan Lau, Lingqiao Tan, Thomas Loy, Alicia Tay, Raman Sethi, Durgalakshmi Sathiakumar, Kaval Kaur, Julia Böhme, Yee-Sin Leo, Laurent Renia, Shanshan W Howland, Amit Singhal, Jinmiao Chen, Katja Fink
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摘要

Clinically important broadly reactive B cells evolve during multiple infections, with B cells re-activated after secondary infection differing from B cells activated after a primary infection. Here we studied CD27CD38 plasmablasts from patients with a primary or secondary dengue virus infection. Three transcriptionally and functionally distinct clusters were identified. The largest cluster 0/1 was plasma cell-related, with cells coding for serotype cross-reactive antibodies of the IgG1 isotype, consistent with memory B cell activation during an extrafollicular response. Cells in clusters 2 and 3 expressed low levels of antibody genes and high levels of genes associated with oxidative phosphorylation, EIF2 pathw... More

关键词

Cell biology, Functional aspects of cell biology, Immunology, Systems biology