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Amber codon is genetically unstable in generation of premature termination codon (PTC)-harbouring Foot-and-mouth disease virus (FMDV) via genetic code expansion

RNA Biol. 2021-04; 
Rongzeng Hao, Kun Ma, Yi Ru, Dan Li, Gaoyuan Song, Bingzhou Lu, Huanan Liu, Yajun Li, Jiaoyan Zhang, Chunping Wu, Guicai Zhang, Haitao Hu, Jianxun Luo, Haixue Zheng
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Molecular Biology Tools The specific primer and probe for BHK-21 Beta-2 microglobulin (BHK-21 B2M) were designed by entering a single BHK-21 B2M exon from GenBank XM_005068531.3 into Genscript’s Real-time PCR (TaqMan) Primer and Probes Design Online Tool. Get A Quote

摘要

The foot-and-mouth disease virus (FMDV) is the causative agent of FMD, a highly infectious and devastating viral disease of domestic and wild cloven-hoofed animals. FMD affects livestock and animal products' national and international trade, causing severe economic losses and social consequences. Currently, inactivated vaccines play a vital role in FMD control, but they have several limitations. The genetic code expansion technology provides powerful strategies for generating premature termination codon (PTC)-harbouring virus as a live but replication-incompetent viral vaccine. However, this technology has not been explored for the design and development of new FMD vaccines. In this study, we first expanded the... More

关键词

Amber codon, foot-and-mouth disease virus, genetic code expansion, genetic stability, premature termination codon (ptc)