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Functional Analysis of the Fusion and Attachment Glycoproteins of Mojiang Henipavirus

Viruses. 2021-03; 
Sofia Cheliout Da Silva, Lianying Yan, Ha V Dang, Kai Xu, Jonathan H Epstein, David Veesler, Christopher C Broder
Products/Services Used Details Operation
ORF cDNA Clones/MolecularCloud MojV (Genbank NC 025352.1) F and G open reading frames (ORFs) were synthesized by GenScript® (Piscataway, NJ, USA) Get A Quote

摘要

Mojiang virus (MojV) is the first henipavirus identified in a rodent and known only by sequence data, whereas all other henipaviruses have been isolated from bats (Hendra virus, Nipah virus, Cedar virus) or discovered by sequence data from material of bat origin (Ghana virus). Ephrin-B2 and -B3 are entry receptors for Hendra and Nipah viruses, but Cedar virus can utilize human ephrin-B1, -B2, -A2 and -A5 and mouse ephrin-A1. However, the entry receptor for MojV remains unknown, and its species tropism is not well characterized. Here, we utilized recombinant full-length and soluble forms of the MojV fusion (F) and attachment (G) glycoproteins in membrane fusion and receptor tropism studies. MojV F and G were fun... More

关键词

Cedar virus, envelope glycoprotein, ephrin ligand, henipavirus, heptad repeat, membrane fusion, mojiang virus, nano luciferase, paramyxoviridae, receptor tropism