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Niclosamide suppresses the expansion of follicular helper T cells and alleviates disease severity in two murine models of lupus via STAT3

J Transl Med. 2021-02; 
Se Gwang Jang, Jaeseon Lee, Seung-Min Hong, Young-Seok Song, Min Jun Kim, Seung-Ki Kwok, Mi-La Cho, Sung-Hwan Park
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摘要

background: Autoantibody production against endogenous cellular components is pathogenic feature of systemic lupus erythematosus (SLE). Follicular helper T (T) cells aid in B cell differentiation into autoantibody-producing plasma cells (PCs). The IL-6 and IL-21 cytokine-mediated STAT3 signaling are crucial for the differentiation to T cells. Niclosamide is an anti-helminthic drug used to treat parasitic infections but also exhibits a therapeutic effect on autoimmune diseases due to its potential immune regulatory effects. In this study, we examined whether niclosamide treatment could relieve lupus-like autoimmunity by modulating the differentiation of T cells in two murine models of lupus. methods: 10-week-old... More

关键词

Follicular helper T cells, MRL/lpr, Niclosamide, R848-induced model, STAT3, Systemic lupus erythematosus