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Modulation of intratumoural myeloid cells, the hallmark of the anti-tumour efficacy induced by a triple combination: tumour-associated peptide, TLR-3 ligand and α-PD-1

Br J Cancer. 2021-02; 
Sara Zalba, Virginia Belsúe, Brian Topp, Dinesh de Alwis, Maite Alvarez, Iñaki F Trocóniz, Pedro Berraondo, María J Garrido
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Mammalian Expression The synthetic peptide DWLKYKDKLKEKLKEALFPDWLKYKDKRAHYNIVTFF that contains the human papillomavirus 16 (HPV16) E7 H2-Db-restricted epitope E7 (49–57) was synthesised by GenScript (New Jersey, USA) Get A Quote

摘要

background: Anti-programmed cell death 1 (PD-1)/programmed death-ligand 1 (PD-L1) monoclonal antibodies (mAbs) show remarkable clinical anti-tumour efficacy. However, rational combinations are needed to extend the clinical benefit to primary resistant tumours. The design of such combinations requires the identification of the kinetics of critical immune cell populations in the tumour microenvironment. methods: In this study, we compared the kinetics of immune cells in the tumour microenvironment upon treatment with immunotherapy combinations with different anti-tumour efficacies in the non-inflamed tumour model TC-1/A9. Tumour-bearing C57BL/6J mice were treated with all possible combinations of a human papillom... More

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