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Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2

Nat Commun. 2021-02; 
Antoni G Wrobel, Donald J Benton, Pengqi Xu, Lesley J Calder, Annabel Borg, Chloë Roustan, Stephen R Martin, Peter B Rosenthal, John J Skehel, Steven J Gamblin
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Mammalian Expression codon optimised for human expression and cloned by GenScript with the same expression and purification tags as described previously for RaTG13 and SARS-CoV-2 S6 viz Get A Quote

摘要

Coronaviruses of bats and pangolins have been implicated in the origin and evolution of the pandemic SARS-CoV-2. We show that spikes from Guangdong Pangolin-CoVs, closely related to SARS-CoV-2, bind strongly to human and pangolin ACE2 receptors. We also report the cryo-EM structure of a Pangolin-CoV spike protein and show it adopts a fully-closed conformation and that, aside from the Receptor-Binding Domain, it resembles the spike of a bat coronavirus RaTG13 more than that of SARS-CoV-2.

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