Products/Services Used | Details | Operation |
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Custom DNA/RNA Oligos> | TaqMan primers and probes for a common region of the HAdV5 hexon were designed with the GenScript Real-Time PCR (TaqMan) Primer Design software (GenScript, Leiden, Netherlands) | Get A Quote |
Human adenoviruses (HAdVs) display a wide range of tissue tropism and can cause an array of symptoms from mild respiratory illnesses to disseminated and life-threatening infections in immunocompromised individuals. However, no antiviral drug has been approved specifically for the treatment of HAdV infections. Herein, we report our continued efforts to optimize salicylamide derivatives and discover compound (JMX0493) as a potent inhibitor of HAdV infection. Compound displays submicromolar IC values, a higher selectivity index (SI > 100) and 2.5-fold virus yield reduction compared to our hit compound niclosamide. Moreover, unlike niclosamide, our mechanistic studies suggest that the antiviral activity of compou... More