至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Discovery of a Small Molecule Inhibitor of Human Adenovirus Capable of Preventing Escape from the Endosome

Int J Mol Sci. 2021-02; 
Jimin Xu, Judith Berastegui-Cabrera, Marta Carretero-Ledesma, Haiying Chen, Yu Xue, Eric A Wold, Jerónimo Pachón, Jia Zhou, Javier Sánchez-Céspedes
Products/Services Used Details Operation
Custom DNA/RNA Oligos TaqMan primers and probes for a common region of the HAdV5 hexon were designed with the GenScript Real-Time PCR (TaqMan) Primer Design software (GenScript, Leiden, Netherlands) Get A Quote

摘要

Human adenoviruses (HAdVs) display a wide range of tissue tropism and can cause an array of symptoms from mild respiratory illnesses to disseminated and life-threatening infections in immunocompromised individuals. However, no antiviral drug has been approved specifically for the treatment of HAdV infections. Herein, we report our continued efforts to optimize salicylamide derivatives and discover compound (JMX0493) as a potent inhibitor of HAdV infection. Compound displays submicromolar IC values, a higher selectivity index (SI > 100) and 2.5-fold virus yield reduction compared to our hit compound niclosamide. Moreover, unlike niclosamide, our mechanistic studies suggest that the antiviral activity of compou... More

关键词

adenovirus, antiviral agent, entry inhibition, salicylamide derivatives