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New Biomarker in Chagas Disease: Extracellular Vesicles Isolated from Peripheral Blood in Chronic Chagas Disease Patients Modulate the Human Immune Response

J Immunol Res. 2021-01; 
Rafael Pedro Madeira, Lavínia Maria Dal'Mas Romera, Paula de Cássia Buck, Charles Mady, Barbara Maria Ianni, Ana Claudia Torrecilhas
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Mammalian Expression Fifty ng/mL phorbol 12-myristate 13-acetate was primed with 10 ng/mL human recombinant interferon-gamma (IFN-γ, GenScript). Get A Quote

摘要

Chagas disease, a neglected tropical disease (NTD) caused by the flagellated protozoan (), is a major public health problem. It was initially restricted to Latin America, but it is now expanding globally. Host and pathogen interactions are crucial in the establishment of disease, and since 1970, it has been known that eukaryotic cells release extracellular vesicles (EVs), which in turn have an important role in intercellular communication in physiological and pathological conditions. Our study proposed to characterize and compare circulating EVs isolated from the plasma of chronic Chagas disease (CCD) patients and controls. For this, peripheral blood was collected from patients and controls, and mononuclear ce... More

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