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Molecular Mechanism of Platelet-Derived Growth Factor (PDGF)-BB-Mediated Protection Against MPP Toxicity in SH-SY5Y Cells

J Mol Neurosci. 2020-11; 
Huan Chen, Yan Teng, Zhihao Liu, Fan Geng, Xingmin Chen, Haisong Jiang, Jing Yang, Min Zheng, Ziyan Wang, Lu Yang
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Mammalian Expression Human recombinant PDGF-BB was purchased from Genscript Get A Quote

摘要

As an important endogenous growth factor, PDGF-BB can effectively promote neurogenesis, thus is considered as a potential agent for Parkinson's disease (PD) therapy. However, the protective function of PDGF-BB on neuronal cells, especially the molecular mechanism, remains less clear, which is needed to explore before its clinical practice. In this study, we investigated the function and mechanism of PDGF-BB against 1-methyl-4-phenylpyridinium (MPP) toxicity in SH-SY5Y cells, a widely used cellular tool for PD-related molecular study. Our results indicated that PDGF-BB exerts a prominent protective effect against neurotoxin MPP-triggered ROS generation and cellular loss. We further dissected the molecular mechan... More

关键词

Akt, CREB, ERK, MPP+, PDGF-BB, Parkinson’s disease