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Erythroid differentiation in mouse erythroleukemia cells depends on Tmod3-mediated regulation of actin filament assembly into the erythroblast membrane skeleton

FASEB J. 2022-03; 
Arit Ghosh, Megan Coffin, Richard West, Velia M Fowler
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Catalog Peptides … (B) Mouse Tmod3 amino acid sequence with locations of peptides (red—Nterm, blue—Cterm) used to prepare custom chicken anti-Tmod3 antibodies (Genscript) … Get A Quote

摘要

Erythroid differentiation (ED) is a complex cellular process entailing morphologically distinct maturation stages of erythroblasts during terminal differentiation. Studies of actin filament (F-actin) assembly and organization during terminal ED have revealed essential roles for the F-actin pointed-end capping proteins, tropomodulins (Tmod1 and Tmod3). Tmods bind tropomyosins (Tpms), which enhance Tmod capping and F-actin stabilization. Tmods can also nucleate F-actin assembly, independent of Tpms. Tmod1 is present in the red blood cell (RBC) membrane skeleton, and deletion of Tmod1 in mice leads to a mild compensated anemia due to mis-regulated F-actin lengths and membrane instability. Tmod3 is not present in R... More

关键词

actin, cell survival, erythrocyte membrane skeleton, tropomodulin, tropomyosin