至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

CircRNA ZNF609 Knockdown Represses the Development of Non-Small Cell Lung Cancer via miR-623/FOXM1 Axis

Cancer Manag Res. 2021-02; 
Fanghan Wang, Xiangfeng Li, Xigao Jia, Luxin Geng
Products/Services Used Details Operation
Custom DNA/RNA Oligos … The primers (Genscript, Nanjing, China) included: circZNF609 (hsa_circ_0000615) (sense, 5'-TGAGTGTCGCCTGCTAAAGA-3'; antisense, 5'-CCCCCAGCTTTCCTATTTTC-3'), FOXM1 … Get A Quote

摘要

unassigned: The dysregulated circular RNAs (circRNAs) are relevant to the development of non-small cell lung cancer (NSCLC). Nevertheless, the function and mechanism of circRNA zinc finger protein 609 (circZNF609) in NSCLC development remain uncertain. unassigned: Sixty-two NSCLC patients were recruited. circZNF609, microRNA-623 (miR-623) and forkhead box M1 (FOXM1) abundances were measured via quantitative reverse transcription polymerase chain reaction or Western blot. Cell viability, apoptosis, migration and invasion were analyzed via cell counting kit-8 (CCK8), flow cytometry, caspase3 activity, transwell assay and Western blot. The interaction between miR-623 and circZNF609 or FOXM1 was analyzed via dual-l... More

关键词

FOXM1, circZNF609, miR-623, non-small cell lung cancer