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Microtubule affinity regulating kinase 4 promoted activation of the NLRP3 inflammasome-mediated pyroptosis in periodontitis

J Oral Microbiol. 2021-12; 
Lulu Wang, Wenchen Pu, Chun Wang, Lang Lei, Houxuan Li
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Custom DNA/RNA Oligos … sequences of the primers for quantitative real-time PCR (qPCR) were inquired by PrimerBank (https://pga.mgh.harvard.edu/primerbank/) and synthesized by Genscript (Genscript, China … Get A Quote

摘要

unassigned: Microtubule dynamics plays a crucial role in the spatial arrangement of cell organelles and activation of the NLRP3 inflammasome. unassigned: This study aimed to explore whether microtubule affinity regulating kinase 4 (MARK4) can be a therapeutic target of periodontitis by affecting microtubule dynamics and NLRP3 inflammasome-mediated pyroptosis in macrophages. unassigned: The NLRP3 inflammasome-related genes and MARK4 were measured in the healthy and inflamed human gingival tissues. Bone marrow-derived macrophages (BMDMs) were infected with Porphyromonas gingivalis, while the MARK4 inhibitors (OTSSP167 and Compound 50) and small interference RNA were utilized to restrain MARK4. Apoptosis-associate... More

关键词

MARK4, NLRP3 inflammasome, Porphyromonas gingivalis, periodontitis, pyroptosis