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KDM5C Expedites Lung Cancer Growth and Metastasis Through Epigenetic Regulation of MicroRNA-133a

Onco Targets Ther. 2021-02; 
Quan Zhang, Lei Xu, Jianjun Wang, Xiaoming Zhu, Zeheng Ma, Junfeng Yang, Jiwei Li, Xiangbo Jia, Li Wei
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Mutant Libraries … edu.cn/). The sequences of PTBP1 3ʹUTR wild-type (wt) or mutant (mt) were constructed by GenScript (Nanjing, Jiangsu, China). Cells were transfected … Get A Quote

摘要

unassigned: KDM5C, a histone H3K4-specific demethylase, possess various biological functions in development of cancers. However, its relation to the microRNA (miRNA) regulation in lung cancer remains unknown. This study aims to study the regulatory role of KDM5C on modification of miR-133a in the progression of lung cancer. unassigned: Differentially expressed miRNAs were filtered from 34 paired lung cancer and paracancerous tissues. The correlation between miR-133a expression and the prognosis of lung cancer patients was determined by a bioinformatics website. Furthermore, malignant aggressiveness of lung cancer cells was detected after miR-133a upregulation by CCK-8, flow cytometry, and Transwell assays and i... More

关键词

KDM5C, PTBP1, histone methylation modification, lung cancer, microRNA-133a