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Assessment on anti-SARS-CoV-2 receptor-binding domain antibodies among CoronaVac-vaccinated Indonesian adults

Clin Exp Vaccine Res. 2022-01; 
Juandy Jo, Astia Sanjaya, Reinhard Pinontoan, Maroloan Aruan, Rury Mega Wahyuni, Venansi Viktaria
Products/Services Used Details Operation
Proteins, Expression, Isolation and Analysis … Second, the GenScript SARS-CoV-2 Surrogate Virus Neutralization Test (sVNT) assay (GenScript, Singapore), an enzyme-linked immunosorbent assay (ELISA), was used to measure … Get A Quote

摘要

The immunogenicity of CoronaVac among Indonesian adults at the academic premises was investigated. Two doses of CoronaVac vaccine induced a complete seroconversion on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) naïve adults with titers of anti-SARS-CoV-2 receptor-binding domain (RBD) antibodies ranging from 9.1 to 151.9 U/mL. The median value was lower than the one observed in recovered adults with mild coronavirus disease 2019 (38.7 vs. 114.5 U/mL). Nonetheless, 93.6% of the vaccinated adults, in contrast to 76.5% of the recovered adults, displayed inhibition rates above the cut-off to block RBD-angiotensin-converting enzyme 2 binding. This suggests that two doses of CoronaVac were immunogeni... More

关键词

Anti-SARS-CoV-2 RBD antibody, COVID-19, CoronaVac vaccine