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Human diamine oxidase cellular binding and internalization in vitro and rapid clearance in vivo are not mediated by N-glycans but by heparan sulfate proteoglycan interactions.

Glycobiology. 2021-05;

Gludovacz E,Schuetzenberger K,Resch M,Tillmann K,Petroczi K,Vondra S,Vakal S,Schosserer M,Virgolini N,Pollheimer J,Salminen TA,Jilma B,Borth N,Boehm T

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Peptide Synthesis	To investigate whether macrophages are capable of internalizing biomolecules via HSPGs, they were incubated with the FITC-labeled cell-penetrating peptides penetratin (RQIKIWFQNRRMKWKK) and TAT (YGRKKRRQRRR) (both FITC-Ahx modified at N-terminus, >85% pure, GenScript).	Get A Quote