| Products/Services Used | Details | Operation |
|---|---|---|
| Recombinant Proteins | … by Genscript (Piscataway, NJ, USA) for rescuing recombinant virus by rg (18). A single amino acid mutation to the AL/39 HA at the residue HA1-Y17H was introduced by site-directed … | Get A Quote |
Despite the accumulation of evidence showing that airborne transmissible influenza A virus (IAV) typically has a lower pH threshold for hemagglutinin (HA) fusion activation, the underlying mechanism for such a link remains unclear. In our study, by using a pair of isogenic recombinant A(H9N2) viruses with a phenotypical difference in virus airborne transmission in a ferret model due to an acid-destabilizing mutation (HA1-Y17H) in the HA, we demonstrate that an acid-stable A(H9N2) virus possesses a multitude of advantages over its less stable counterpart, including better fitness in the ferret respiratory tract, more effective aerosol emission from infected animals, and improved host susceptibility. Our study pr... More
