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A novel vaccine strategy using quick and easy conversion of bacterial pathogens to unnatural amino acid-auxotrophic suicide derivatives

Microbiol Spectr. 2024-02; 
Yuya Nagasawa, Momoko Nakayama, Yusuke Kato, Yohsuke Ogawa, Swarmistha Devi Aribam, Yusaku Tsugami, Taketoshi Iwata, Osamu Mikami, Aoi Sugiyama, Megumi Onishi, Tomohito Hayashi, Masahiro Eguchi
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Gene Synthesis … Plasmids A-2, A-3, and C-2 were constructed using gene synthesis outsourced to GenScript (Tokyo, Japan). Plasmid B-2 is 2a-IYRS(M6V) described in our previous paper (42). … Get A Quote

摘要

关键词

bacterial pathogens, toxin-antitoxin systems, unnatural amino acids, vaccine development strategy
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