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Rupatadine-inhibited OTUD3 promotes DLBCL progression and immune evasion through deubiquitinating MYL12A and PD-L1

Cell death & disease. 2024-08; 
Ying Sui , Ziyang Shen, Xiaoyou Li 1, Ya Lu , SiTong Feng , Rong Ma, Jianzhong Wu , Changwen Jing, Zhuo Wang, Jifeng Feng , Haixia Cao
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Proteins, Expression, Isolation and Analysis These were loaded into a precast gel (GenScript, China) and subjected to constant voltage electrophoresis at 140 V until the bromophenol blue reached its bottom. Get A Quote

摘要

The obstacle to effectively treating Diffuse Large B-cell Lymphoma (DLBCL) lies in the resistance observed toward standard therapies. Identifying therapeutic targets that prove effective for relapsed or refractory patients poses a significant challenge. OTUD3, a deubiquitinase enzyme, is overexpressed in DLBCL tissues. However, its role in DLBCL has not been investigated. Our study has brought to light the multifaceted impact of OTUD3 in DLBCL. Not only does it enhance cell survival through the deubiquitination of MYL12A, but it also induces CD8+ T cell exhaustion within the local environment by deubiquitinating PD-L1. Our findings indicate that the OTUD3 inhibitor, Rupatadine, exerts its influence through comp... More

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