Products/Services Used | Details | Operation |
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Recombinant Proteins> | nterleukin-4 (IL-4) and Granulocyte Macro-phage Colony Stimulating Factor (GM-CSF) were obtained from GenScript Biotech Corporation. All antibodies for flow cytometry analysis were used from BioLegend (USA). | Get A Quote |
The effectiveness of immune checkpoint blockade therapies in treating solid tumors is hindered by the limited activation of the tumor immune microenvironment within deep tumors. Immunogenic cell death offers a promising method to enhance anti-tumor immune responses. Integrating these two approaches in cancer chemoimmunotherapy presents a novel perspective. Here, a self-mineralized bioorthogonal probiotic platform with the expression of anti-PD-L1 nanobodies was developed for cancer chemoimmunotherapy. This platform selectively accumulated and deeply penetrated into tumor tissues, where the palladium-mineralized probiotics catalyzed bioorthogonal bond-cleavage to generate chemotherapeutic drugs and induced immun... More