至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Identification of antimicrobial bioactive peptides from the camel milk protein lactoferrin: Molecular docking, molecular dynamic simulation, and in vitro study

food and humanity. 2024-09; 
Mohammed Alzain , Ehab M.M. Ali , Mazin Zamzami , Ishtiaq Qadri , Hani Choudhry , Kamel Chaieb , Bochra Kouidhi , Hisham N. Altayb
Products/Services Used Details Operation
Peptide Synthesis The lactoferrin-derived peptides selected in this study for in vitro analysis were purchased from GenScript Biotech Corporation (Piscataway, NJ, USA) with a purity of ≥ 95 %. Get A Quote

摘要

This study explores the potential of antimicrobial peptides (AMPs) derived from camel milk lactoferrin as novel agents against antibiotic-resistant pathogens. Through in silico screening and molecular dynamics simulations, seven lactoferrin-derived peptides were identified as potential AMPs, with peptides P1 and P33 showing promising inhibitory effects against methicillin-resistant Staphylococcus aureus (MRSA). In vitro assays confirmed the efficacy of P33 against pathogenic strains, notably exhibiting activity against multi-drug-resistant strains. Moreover, the lactoferrin-derived peptide P33 demonstrated relatively low cytotoxicity on human fibroblast cells. These findings suggest that P33 holds significant p... More

关键词