Products/Services Used | Details | Operation |
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Peptide Synthesis> | The lactoferrin-derived peptides selected in this study for in vitro analysis were purchased from GenScript Biotech Corporation (Piscataway, NJ, USA) with a purity of ≥ 95 %. | Get A Quote |
This study explores the potential of antimicrobial peptides (AMPs) derived from camel milk lactoferrin as novel agents against antibiotic-resistant pathogens. Through in silico screening and molecular dynamics simulations, seven lactoferrin-derived peptides were identified as potential AMPs, with peptides P1 and P33 showing promising inhibitory effects against methicillin-resistant Staphylococcus aureus (MRSA). In vitro assays confirmed the efficacy of P33 against pathogenic strains, notably exhibiting activity against multi-drug-resistant strains. Moreover, the lactoferrin-derived peptide P33 demonstrated relatively low cytotoxicity on human fibroblast cells. These findings suggest that P33 holds significant p... More