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Reduced Cross-Protective Potential of Omicron Compared to Ancestral SARS-CoV-2 Spike Vaccines Against Potentially Zoonotic Coronaviruses

npj Viruses. 2024-08; 
Tyler RennerMatthew StuibleBrian CassSylvie PerretJulie GuimondSimon Lord-DufourMichael J. McCluskieYves DurocherBassel Akache
Products/Services Used Details Operation
Gene Synthesis CHO codon-optimized sequences encoding spike ectodomains of animal-origin sarbecoviruses (with prefusion-stabilizing 2P mutations) fused to human resistin and purification tags (FLAG-dual-Strep-6His or dual-Strep-6His) at the C-terminus were synthesized at Genscript and cloned into the pTT241® plasmid . Get A Quote
PCR Cloning and Subcloning Get A Quote

摘要

The COVID-19 pandemic has emphasised the importance of vaccines and preparedness against viral threats crossing species barriers. In response, a worldwide vaccination campaign targeting SARS-CoV-2 was implemented, which provides some cross-protective immunological memory to other coronavirus species with zoonotic potential. Following a vaccination regimen against SARS-CoV-2 spike in a preclinical mouse model, we were able to demonstrate the induction of neutralizing antibodies towards multiple human ACE2 (hACE2)-binding sarbecovirus spikes. Importantly, compared to vaccines based on the SARS-CoV-2 Reference strain, vaccines based on Omicron spike sequences induced drastically less broadly cross-protective neutr... More

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