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Live-imaging rate-of-kill compound profiling for Chagas disease drug discovery with a new automated high-content assay
Authors: Nina Svensen, Susan Wyllie, David W Gray, Manu De Rycker
Journal: PLoS Negl Trop Dis
PubMed ID: 34634052
Doi: 10.1371/journal.pntd.0009870
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Crystallographic approach to fragment-based hit discovery against Schistosoma mansoni purine nucleoside phosphorylase
Authors: Muhammad Faheem, Napoleão Fonseca Valadares, José Brandão-Neto, Dom Bellini, Patrick Collins, Nicholas M Pearce, Louise Bird, Juliana Roberta Torini, Raymond Owens, Humberto DMuniz Pereira, Frank Von Delft, João Alexandre Ribeiro Gonçalves Barbosa
Journal: Biochem J
PubMed ID: 34529035
Doi: 10.1042/BCJ20210041
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De novo biosynthesis of bioactive isoflavonoids by engineered yeast cell factories
Authors: Quanli Liu, Yi Liu, Gang Li, Otto Savolainen, Yun Chen, Jens Nielsen
Journal: Nat Commun
PubMed ID: 34667183
Doi: 10.1038/s41467-021-26361-1
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Binding of de novo synthesized radiolabeled juvenile hormone (JH III) by JH receptors from the Cuban subterranean termite Prorhinotermes simplex and the German cockroach Blattella germanica
Authors: Matej Milacek, Lenka Bittova, Sarka Tumova, Ondrej Luksan, Robert Hanus, Pavlina Kyjakova, Ales Machara, Ales Marek, Marek Jindra
Journal: Insect Biochem Mol Biol
PubMed ID: 34656795
Doi: 10.1016/j.ibmb.2021.103671
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Engineering transcriptional regulation in Escherichia coli using an archaeal TetR-family transcription factor
Authors: David Sybers, Amber Joka Bernauw, Diala El Masri, Hassan Ramadan Maklad, Daniel Charlier, Marjan De Mey, Indra Bervoets, Eveline Peeters
Journal: Gene
PubMed ID: 34688814
Doi: 10.1016/j.gene.2021.146010
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The glycan hole area of HIV-1 envelope trimers contributes prominently to the induction of autologous neutralization
Authors: Anna Schorcht, Christopher A Cottrell, Pavel Pugach, Rajesh P Ringe, Alvin X Han, Joel D Allen, Tom L G M van den Kerkhof, Gemma E Seabright, Edith E Schermer, Thomas J Ketas, Judith A Burger, Jelle van Schooten, Celia C LaBranche, Gabriel Ozorowski, Natalia de Val, Daniel L V Bader, Hanneke Schuitemaker, Colin A Russell, David C Montefiori, Marit J van Gils, Max Crispin, P J Klasse, Andrew B Ward, John P Moore, Rogier W Sanders
Journal: J Virol
PubMed ID: 34669426
Doi: 10.1128/JVI.01552-21
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Enhanced bone regeneration via spatiotemporal and controlled delivery ofa genetically engineered BMP-2 in a composite Hydrogel
Authors: Xin Chen , Baoyu Tan , Zhiteng Bao , Shang Wang , Rongze Tang , Zhenmin Wang , Gaoyang Chen , Shuai Chen , William W Lu , Dazhi Yang , Songlin Peng
Journal: Biomaterials
PubMed ID: 34517277
Doi: doi.org/10.1016/j.biomaterials.2021.121117
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Pathways of thymidine hypermodification
Authors: Yan-Jiun Lee, Nan Dai, Stephanie I Müller, Chudi Guan, Mackenzie J Parker, Morgan E Fraser, Shannon E Walsh, Janani Sridar, Andrew Mulholland, Krutika Nayak, Zhiyi Sun, Yu-Cheng Lin, Donald G Comb, Katherine Marks, Reyaz Gonzalez, Daniel P Dowling, Vahe Bandarian, Lana Saleh, Ivan R Corrêa, Peter R Weigele
Journal: Nucleic Acids Res
PubMed ID: 34522950
Doi: 10.1093/nar/gkab781
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A Novel Miniature CRISPR-Cas13 System for SARS-CoV-2 Diagnostics
Authors: Ahmed Mahas, Qiaochu Wang, Tin Marsic, Magdy M Mahfouz
Journal: ACS Synth Biol
PubMed ID: 34546709
Doi: 10.1021/acssynbio.1c00181
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Safety and efficacy of an engineered hepatotropic AAV gene therapy for ornithine transcarbamylase deficiency in cynomolgus monkeys
Authors: Julien Baruteau, Sharon C Cunningham, Berna Seker Yilmaz, Dany P Perocheau, Simon Eaglestone, Derek Burke, Adrian J Thrasher, Simon N Waddington, Leszek Lisowski, Ian E Alexander, Paul Gissen
Journal: Mol Ther Methods Clin Dev
PubMed ID: 34703837
Doi: 10.1016/j.omtm.2021.09.005
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