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A brain-targeting lipidated peptide for neutralizing RNA-mediated toxicity in Polyglutamine Diseases

Authors: Anne Cathrine Nøhr , Willem Jespers, Mohamed A. Shehata , Leonard Floryan, Vignir Isberg , Kirsten Bayer Andersen, Johan Åqvist, Hugo Gutiérrez-de-Terán , Hans Bräuner-Osborne & David E. Gloriam

Journal: Scientific REPORTS

Doi: 10.1038/s41598-017-01049-z

Products & Services: Mutagenesis Services

Expression optimization of a cell membrane-penetrating human papillomavirus type 16 therapeutic vaccine candidate in Nicotiana benthamiana

Authors: Renata de A. B. Assis Lorraine Cristina Polloni, José S. L. Patané, Shalabh Thakur, Érica B. Felestrino, Julio Diaz-Caballero, Luciano Antonio Digiampietri , Luiz Ricardo Goulart, Nalvo F. Almeida , Rafael Nascimento, Abhaya M. Dandekar, Paulo A. Zaini João C. Setubal, David S. Guttman & Leandro Marcio Moreira

Journal: Scientific Reports,

Doi: 10.1038/s41598-017-16325-1

Products & Services: Mutagenesis Services

The GPR139 reference agonists 1a and 7c， and tryptophan and phenylalanine share a common binding site.

Authors: NøhrAnne Cathrine，JespersWillem，ShehataMohamed A，FloryanLeonard，IsbergVignir，AndersenKirsten Bayer，ÅqvistJohan，Gutiérrez-de-TeránHugo，Bräuner-OsborneHans，GloriamDav

Journal: Sci Rep

PubMed ID: 28442765

Doi: 10.1038/s41598-017-01049-z

Products & Services: Mutagenesis Services

Rational Modular RNA Engineering Based on In Vivo Profiling of Structural Accessibility.

Authors: LeistraAbigail N，AmadorPaul，BuvanendiranAishwarya，Moon-WalkerAlex，ContrerasLyd

Journal: ACS Synth Biol

PubMed ID: 28796489

Doi: 10.1021/acssynbio.7b00185

Products & Services: Mutagenesis Services

The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive， pseudokinase-like conformation.

Authors: LisaMaría-Natalia，WagnerTristan，AlexandreMatthieu，BariloneNathalie，RaynalBertrand，AlzariPedro M，BellinzoniM

Journal: FEBS J.

PubMed ID: 28054744

Doi: 10.1111/febs.14003

Products & Services: Mutagenesis Services

Structural and Biological Interaction of hsc-70 Protein with Phosphatidylserine in Endosomal Microautophagy.

Authors: MorozovaKateryna，ClementCristina C，KaushikSusmita，StillerBarbara，AriasEsperanza，AhmadAtta，RauchJennifer N，ChatterjeeVictor，MelisChiara，ScharfBrian，GestwickiJason E，CuervoAna-Maria，ZuiderwegErik R P，SantambrogioL

Journal: J. Biol. Chem.

PubMed ID: 27405763

Doi: 10.1074/jbc.M116.736744

Products & Services: Mutagenesis Services

The prevalent deep intronic c. 639+919 GNA GLA mutation causes pseudoexon activation and Fabry disease by abolishing the binding of hnRNPA1 and hnRNP A2/B1 to a splicing silencer

Authors: Palhais B, Dembic M, Sabaratnam R, Nielsen KS, Doktor TK, Bruun GH, Andresen BS.

Journal: Mol Genet Metab

PubMed ID: 27595546

Doi: 10.1016/j.ymgme.2016.08.007

Products & Services: Mutagenesis Services

Susceptibility of Mutant SOD1 to Form a Destabilized Monomer Predicts Cellular Aggregation and Toxicity but Not In vitro Aggregation Propensity

Authors: McAlary L, Aquilina JA, Yerbury JJ.