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Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells

Authors: Chadchankar J1, Korboukh V2, Conway LC1, Wobst HJ3, Walker CA3, Doig P2, Jacobsen SJ3, Brandon NJ3, Moss SJ3,4,5, Wang Q3.

Journal: PLoS One.

PubMed ID: 31703099

Doi: 10.1371/journal.pone.0225145

Products & Services: Mutant Libraries

Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing

Authors: Pan D1, Walstein K2, Take A2, Bier D2, Kaiser N3, Musacchio A4,5.

Journal: Nat Commun.

PubMed ID: 31492860

Doi: 10.1038/s41467-019-12019-6

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Selection of an Efficient AAV Vector for Robust CNS Transgene Expression

Authors: Hanlon KS1,2,3, Meltzer JC3,4, Buzhdygan T5,6,7, Cheng MJ2,3, Sena-Esteves M8, Bennett RE3,4, Sullivan TP5,6,7, Razmpour R5,6,7, Gong Y2,3, Ng C2,3, Nammour J2,3, Maiz D3,4, Dujardin S3,4, Ramirez SH5,6,7, Hudry E3,4, Maguire CA2,3.

Journal: Mol Ther Methods Clin Dev.

PubMed ID: 31788496

Doi: 10.1016/j.omtm.2019.10.007

Products & Services: Mutant Libraries

Patient-Driven Discovery, Therapeutic Targeting, and Post-Clinical Validation of a Novel AKT1 Fusion-Driven Cancer

Authors: Slotkin EK#1, Diolaiti D#2, Shukla NN2, Dela Cruz FS2, Clark JJ3, Gundem G4, Yellapantula VD4, Levine MF4, You D2, Ma P2, Pachhal S2, Ibanez Sanchez G2, Benayed R5, Jungbluth AA5, Smyth LM6, Mauguen A4, Gushterova I7, Ding H7, Spraggon L8, Darnell R9, Califano A7, Ladanyi M5, Papaemmanuil E4, Kung AL2, Hyman DM6, Roberts SS2.

Journal: Cancer Discov.

PubMed ID: 30877085

Doi: 10.1158/2159-8290.CD-18-0953

Products & Services: Mutant Libraries

Excited State Structural Evolution of a GFP Single-Site Mutant Tracked by Tunable Femtosecond-Stimulated Raman Spectroscopy

Authors: Longteng Tang, Liangdong Zhu, Miles A Taylor, Yanli Wang, S James Remington, Chong Fang

Journal: Molecules

PubMed ID: 30200474

Doi: 10.3390/molecules23092226

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Intracellular delivery of peptide drugs using viral nanoparticles of bacteriophage P22: covalent loading and cleavable release

Authors: Jigang Wang, Ti Fang, Ming Li, Wenjing Zhang, Zhi-Ping Zhang, Xian-En Zhang, Feng Li

Journal: J Mater Chem B

PubMed ID: 32254834

Doi: 10.1039/c8tb00186c

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Mapping the in vivo fitness landscape of lung adenocarcinoma tumor suppression in mice

Authors: Zoë N Rogers, Christopher D McFarland, Ian P Winters, Jose A Seoane, Jennifer J Brady, Stephanie Yoon, Christina Curtis, Dmitri A Petrov, Monte M Winslow

Journal: Nat Genet

PubMed ID: 29610476

Doi: 10.1038/s41588-018-0083-2

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Specific Activation of the Alternative Cardiac Promoter of Cacna1c by the Mineralocorticoid Receptor

Authors: Mesquita TR, Auguste G, Falcón D, Ruiz-Hurtado G, Salazar-Enciso R, Sabourin J, Lefebvre F, Viengchareun S, Kobeissy H, Lechène P, Nicolas V, Fernandez-Celis A, Gómez S, Lauton Santos S, Morel E, Rueda A, López-Andrés N, Gómez AM, Lombès M, Benitah JP

Journal: Circulation research

PubMed ID: 29467196

Doi: 10.1161/CIRCRESAHA.117.312451

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Drosophila melanogaster Guk-holder interacts with the Scribbled PDZ1 domain and regulates epithelial development with Scribbled and Discs Large.

Authors: CariaSofia，MagtotoCharlene M，SamieiTinaz，PortelaMarta，LimKrystle Y B，HowJing Yuan，StewartBryce Z，HumbertPatrick O，RichardsonHelena E，Kvansakul

Journal: J. Biol. Chem.

PubMed ID: 29378849

Doi: 10.1074/jbc.M117.817528

Products & Services: Mutant Libraries Peptide Synthesis

Tau protein disrupts nucleocytoplasmic transport in Alzheimer's disease

Authors: BaharehEftekharzadehJ. GavinDaigleLarisa E.KapinosAlyssaCoyneJuliaSchiantarelliYariCarlomagnoCaseyCookSean J.MillerSimonDujardinAna S.AmaralJonathan C.GrimaRachel E.BennettKatharinaTepperMichaelDeTureCharles R.VanderburgBianca T.CorjucSarah L.DeVosJose AntonioGonzalez…Bradley T.Hyman

Journal: Neuron

Doi: 10.1016/j.neuron.2018.07.039

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