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FGFR1 expression correlates inversely with the efficacy of single-agent FGFR-specific inhibitors in pancreatic cancer

Authors: Qingxiang Lin, Andrea Serratore, Jonathan Perri, Tista Roy Chaudhuri, Jun Qu, Wen Wee Ma, Eugene Kandel, Robert M Straubinger

Journal: Br J Pharmacol

PubMed ID: 37994108

Doi: 10.1111/bph.16289

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Functional characterization of a lytic polysaccharide monooxygenase from Schizophyllum commune that degrades non-crystalline substrates

Authors: Heidi Østby, Idd A Christensen, Karen Hennum, Anikó Várnai, Edith Buchinger, Siri Grandal, Gaston Courtade, Olav A Hegnar, Finn L Aachmann, Vincent G H Eijsink

Journal: Sci Rep

PubMed ID: 37833388

Doi: 10.1038/s41598-023-44278-1

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Loss of ATG4B and ATG4A results in two-stage cell cycle defects in pancreatic ductal adenocarcinoma cells

Authors: Paalini Sathiyaseelan, Suganthi Chittaranjan, Steve E Kalloger, Jennifer Chan, Nancy E Go, Mario A Jardon, Cally J Ho, Theodore Hui, Jing Xu, Christine Chow, Dongxia Gao, Fraser D Johnson, William W Lockwood, Gregg B Morin, Daniel J Renouf, David F Schaeffer, Sharon M Gorski

Journal: J Cell Sci

PubMed ID: 37701987

Doi: 10.1242/jcs.260644

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Improved Stability and Manufacturability of Nucleocapsid Antigens for SARS-CoV2 Diagnostics through Protein Engineering

Authors: Esha Shukla, Lipsa Choudhury, Saurabh Rastogi, Arshmeet Chawla, Sanghati Bhattacharya, Umesh Kaushik, Manan Mittal, Anurag Singh Rathore, Gaurav Pandey

Journal: Biomolecules

PubMed ID: 37892206

Doi: 10.3390/biom13101524

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Proteomic Analysis Reveals a PLK1-Dependent G2/M Degradation Program and Links PKA-AKAP2 to Cell Cycle Control

Authors: Ryan D Mouery, Carolyn Hsu, Thomas Bonacci, Derek L Bolhuis, Xianxi Wang, Christine A Mills, E Drew Toomer, Owen G Canterbury, Kevin C Robertson, Timothy B Branigan, Nicholas G Brown, Laura E Herring, Michael J Emanuele

Journal: biorxiv

PubMed ID: 37873169

Doi: 10.1101/2023.10.11.561963

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Disruption of sugar nucleotide clearance is a therapeutic vulnerability of cancer cells

Authors: Mihir B Doshi, Namgyu Lee, Tenzin Tseyang, Olga Ponomarova, Hira Lal Goel, Meghan Spears, Rui Li, Lihua Julie Zhu, Christopher Ashwood, Karl Simin, Cholsoon Jang, Arthur M Mercurio, Albertha J M Walhout, Jessica B Spinelli, Dohoon Kim

Journal: Nature

PubMed ID: 37880368

Doi: 10.1038/s41586-023-06676-3

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Electroacupuncture at GB20 improves cognitive ability and synaptic plasticity via the CaM-CaMKII-CREB signaling pathway following cerebral ischemia-reperfusion injury in rats

Authors: Qing Han, Feng Wang

Journal: Acupunct Med

PubMed ID: 38126262

Doi: 10.1177/09645284231202805

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Replenishing decoy extracellular vesicles inhibits phenotype remodeling of tissue-resident cells in inflammation-driven arthritis

Authors: Mengmeng Liang, Ke Wang, Xiaoyu Wei, Xiaoshan Gong, Hao Tang, Hao Xue, Jing Wang, Pengbin Yin, Licheng Zhang, Zaisong Ma, Ce Dou, Shiwu Dong, Jianzhong Xu, Fei Luo, Qinyu Ma

Journal: Cell Rep Med

PubMed ID: 37852176

Doi: 10.1016/j.xcrm.2023.101228

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Molecularly targetable cell types in mouse visual cortex have distinguishable prediction error responses

Authors: Sean M O'Toole, Hassana K Oyibo, Georg B Keller

Journal: Neuron

PubMed ID: 37708892

Doi: 10.1016/j.neuron.2023.08.015

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The H163A mutation unravels an oxidized conformation of the SARS-CoV-2 main protease

Authors: Norman Tran, Sathish Dasari, Sarah A E Barwell, Matthew J McLeod, Subha Kalyaanamoorthy, Todd Holyoak, Aravindhan Ganesan

Journal: Nat Commun

PubMed ID: 37699927

Doi: 10.1038/s41467-023-40023-4

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